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DOV 216,303 is an antidepressant drug originally developed by DOV Pharmaceutical and now licensed to the larger pharmaceutical company Merck & Co., which is currently in clinical trials. It is a so-called triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).〔 It is the racemic mixture of amitifadine (DOV 21,947) and its (–)-enantiomer. Its IC50 values for SERT, NET, and DAT are Ki 14 nM, 20 nM, and 78 nM, respectively.〔 It is closely related to DOV 102,677 and amitifadine, both of which are also being developed in collaboration with Merck. 500px *Doses of up to 100 mg per day are well tolerated with only nausea, and GI disturbances reported as side effects. *This compound does not cause notable shifts in LMA, and is not psychostimulant. The effects are not long-lasting. More recently (see attachment), it appears that the DOV compound may also be useful at increasing weight loss. *DOV causes a decrease in circulating triglycerides. *The reason for weightloss is not going to be thermogenic or psychostimulant, or chronic decrease appetite. Read article for details. ==See also== * Bicifadine 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「DOV-216,303」の詳細全文を読む スポンサード リンク
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